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Science Newsletter of the Faculty fo Physics
This is a new bulletin, which, as we hope, will bring fresh, updated information on scientific news, research activities, and related events in the life of our department to our staff members, undegraduate and graduate students, postdocs, collaborators and partners. We greatly hope that this Science Newsletter will help us to find new partners in research and shorten the way from fundamental research to applications and innovations, from our fundamental discoveries to their successful implementations in not too distant future.
XIV National School-Seminar "Wave phenomena in inhomogeneous media"
The conference papers from the School-Seminar «Waves-2014» will be submitted for publishing in the Memoirs of the Faculty of Physics journal.
| Journals » Memoirs of the Faculty of Physics » Issues » 2014 » # 5 |
Histological analysis of mechanical lesions induced by high intensity focused ultrasound in ex-vivo human and porcine kidneys
V.A. Khokhlova, Y.-N. Wang, S.V. Buravkov, A.D. Maxwell, T.D. Khokhlova, D.W. Lin, O.A. Sapozhnikov, M.R. Bailey, G.R. Schade
1. V.A. Khokhlova, Physics Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia 2. Y.-N. Wang - Center for Industrial and Medical Ultrasound, University of Washington, Seattle, WA, USA 3. S.V. Buravkov – Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia 4. A.D. Maxwell, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USA 5. T.D. Khokhlova, Department of Gastroenterology, School of Medicine, University of Washington, Seattle, WA, USA 6. D.W. Lin, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USA 7. O.A. Sapozhnikov, Physics Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia 8. M.R. Bailey - Center for Industrial and Medical Ultrasound, University of Washington, Seattle, WA, USA 9. G.R. Schade, Department of Urology, School of Medicine, University of Washington, Seattle, WA, USAMost current clinical applications of high intensity focused ultrasound in noninvasive surgery (HIFU) rely on the rapid heating of the propagation medium caused by absorption of the ultrasound wave energy, which results in thermal denaturation of tissue in the focal region of ultrasound beam. Recently, scientists from the University of Washington and Moscow State University have developed a new method to mechanically destroy tissue using pulse-periodic focused waves with high amplitude shock fronts. Such millisecond duration pulses cause ultrafast heating of tissue at the focus and explosive boiling in tissue during each of the pulses. Interaction of shock fronts with millimeter size vapor-gas cavity leads to mechanical disintegration of tissue into subcellular fragments. The efficiency of the method has already been shown in ex-vivo tissues of bovine liver and heart, as well as in porcine kidney in-vivo. In this paper, mechanically disintegrated lesions obtained in ex-vivo human and porcine kidney tissues were analyzed histologically. The results of comparative histological studies are discussed.
| URL: | http://uzmu.phys.sunmarket.com/abstract/2014/5/145343 |
| PACS: | 43.35.Wa Biological effects of ultrasound, ultrasonic tomography 43.25.+y Nonlinear acoustics |
| UDC: | 534.2 |
| Цитата: | В.А. Хохлова, Я.Н. Ванг, С.В.Буравков, А.Д. Максвелл, Т.Д. Хохлова, Д.В. Лин, O.A. Сапожников, М.Р. Бэйли, Дж.Р. Шэйд. Гистологичесий анализ механических разрушений в ex-vivo почках человека и свиньи под действием высокоинтенсивного фокусированного ультразвука // Учен. зап. физ. фак-та Моск. ун-та. 2014. № 5. 145343 |